Nociplastic pain

Nociplastic pain

Pain phenotyping is a challenging issue. Three mechanistic pain descriptors have been identified including nociceptive, neuropathic and nociplastic pain

The IASP has defined nociplastic pain as pain that arises from altered nociception despite no clear evidence of actual or threatened tissue damage causing the activation of peripheral nociceptors or evidence for disease or lesion of the somatosensory system causing the pain

Nociplastic pain is the third mechanistic descriptor of chronic pain and refers to the pain resulting from the maintenance of central sensitization mechanisms

Central sensitization is neurophysiological mechanism, defined as amplification of neural signalling within the central nervous system that elicits pain hypersensitivity

Nociplastic pain is mechanistically distinct from nociceptive pain, which is caused by ongoing inflammation and damage of tissues, and neuropathic pain, which is caused by nerve damage

The mechanisms that underlie this type of pain are not entirely understood, but it is thought that augmented CNS pain and sensory processing and altered pain modulation play prominent roles

Nociplastic pain is the same as Neuroplastic pain

Both are forms of Chronic primary pain